/>i- On July 30, 2025, the U.S. Food and Drug Administration (FDA) released its Expanded Decision Tree (EDT) chemical toxicity and risk screening tool in connection with the agency’s food chemical safety program. FDA claims that the tool will provide a “consistent, systematic, and science-based approach to support evaluation of the safety of chemicals in food based on their structure and estimated toxicity.”
- FDA submitted the EDT for external peer review in March 2024, which collected input from external scientific experts pursuant to Information Quality Act requirements. The EDT was updated based on this review and FDA has now publicly released it to the scientific community for technical consideration. FDA will also develop software for the EDT for general public use and will further refine the EDT over time.
- The EDT approach is a modernized version of the Cramer Decision Tree tool and will be used to screen chemicals based on their structural features. The updated, expanded, and refined set of fully chemical structure-based questions in FDA’s EDT allows classification of chemicals with greater specificity than the Cramer Decision Tree, according to FDA. It expects the EDT to eventually be used in both pre- and post-market evaluation of chemicals in food.
- FDA intends to release an informational video to explain the EDT and will hold listening sessions to receive input from interested parties.
FDA Releases Tool for Toxicity Screening of Chemicals in Food
Sunday, August 3, 2025
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